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Reconstruction of Irradiated Bone Defect with Bioceramics: Pre-Clinical Studies
by F. Jegoux 1, O. Malard 1, E. Aguado 2, F.Moreau 3, E. Goyenvalle 2, G. Daculsi 1,4
1 INSERM U791, University de Nantes; Osteoarticular and dental tissue engineering research center, Faculty de chirurgie dentaire, place Alexis Ricordeau, 44042 Nantes cedex, France
2 ENVN, LBBTOC ex, National Veterinary School of Nantes, route de Gachet, Nantes
3 Biomatlante SAS, Vigneux de Bretagne France ,
4 INSERM and CHU de Bordeaux, CIC-IT 802 Biomaterials, PTIB Hopital Xavier Arnozan, 33600 Pessac, France
Abstract
Current bone tissue engineering models would not be recommended for maxillofacial oncological defects because an immediate post implantation irradiation would decrease their osteoinductive potential. The aim of this study was to reconstruct bone defects applying the concept of a bone marrow graft after the initial reconstruction and radiotherapy. Segmental defects were created in femoral diaphysis of Zealand rabbits, and femoral critical sized defect in a canine model. Defects were immediately filled with micro macroporous biphasic calcium phosphate granules (MBCP+®). After soft tissue wound healing and application of a daily radiation for 4 weeks, a total autologous bone marrow graft (BM) was injected percutaneously in the core of the implant. Successful osseous colonization was found suggesting an osteoinduction role of the bone marrow graft in the center of the defect after radiotherapy. This procedure may be considered as a preclinical study for bone tissue engineering approach to patients with cancer-related bone defects.
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