ISSN 0004-881X

Effect of Substitution Li₂O for Na₂O on Surface Reactivity and Cellular Properties of 45S5 Bioglass

by M. Khorami, S. Hesaraki, A.A. Behnamghader, M. Alizadeh, S. Farhangdoust

Department, Materials and Energy Research Center, Karaj, Iran

Abstract

There are some reports that confirm the increasing effect of orally administered lithium on bone density. In this study, different concentrations of Li₂O was substituted for Na₂O in 45S5 bioglass and effect of these substitutions on both in vitro apatite formation ability and osteoblasts responses was studied. The XRD and FTIR results revealed that carbonated nanoapatite phase precipitated on the surface of all glasses after storing them in SBF. It was observed that low concentration of Li₂O substituted for Na₂O in the glass composition retarded formation of apatite layer while bioactivity of 45S5 was recovered when Na₂O was replaced by 12 wt% Li₂O. The nanoapatite crystallites formed on Li-containing glasses were smaller than Li-free samples. It was also found that proliferation rate and alkaline phosphatase activity of the osteoblasts cultured on Li-doped glasses were higher than those of Li-free samples in a dose dependent manner.

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