ISSN 0004-881X

Novel composites using hydrogel and BCP granules: Preclinical studies

by G. Daculsi^1,2, AP. Uzel^1,3, E. Goyenvalle⁴, E. Aguado⁴, P. Pilet⁵, F. Moreau⁶, P. Borget⁶, S. Baroth⁶

1) INSERM U791, Université de Nantes; Osteoarticular and dental tissue engineering research center, Faculté de chirurgie dentaire, place Alexis Ricordeau, 44042 Nantes cedex, France
2) CIC INSERM, CHU de Bordeaux, Université de Bordeaux, PTIB Hôpital Xavier Arnozan, France
3) Service d'orthopédie-traumatologie, CHU Pointe-à-Pitre, 97159 Pointe à Pitre, Guadeloupe, France
4) ENVN, LBBTOC ex, National Veterinary School of Nantes, route de Gachet, Nantes France
5) Université de Nantes, SC3M Regional microscopic center, , Faculté de chirurgie dentaire, Nantes France
6) Biomatlante SA, Vigneux de Bretagne France

Abstract

Calcium phosphate bioceramic granules associated with hydrosoluble polymers were developed as bone substitutes for various maxillofacial and orthopaedic applications. These resorbable bone substitute putties, support and regenerate bone tissue after implantation. The efficiency of these multiphasic materials is due to the osteogenic and osteoconductive properties of the microporous biphasic calcium phosphate bioceramic. The associated hydrosoluble polymers are considered as carriers in order to achieve the rheological properties of putty mouldable bone substitutes. In this study, 2 types of hydrosoluble polymers were tested. The first one is a thermo reversible polymer (polaxamer) and the second one is a reticulated hydrogel (polysaccharidic) obtain by e-beam irradiation. The 2 types of hydrogels were associated to microporous biphasic calcium phosphate (HA/TCP) bioceramics and implanted in goat vertebrae bodies. No foreign body reactions were observed in the two samples. This study demonstrates good handling of the two putties, good biocompatibility, high resorbability and bone ingrowth at the expense of the materials.

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